Ascension Orthopedics (Austin, TX) developer of surgical implants for joint replacement, trauma and tissue regeneration closed a $21M Series D financing, Participants include return investor Frazier Healthcare Ventures.

Cayenne Medical (Scottsdale, AZ) medical device company focused on ACL fixation raised $12.7M in Series B funding. Participants included Split Rock Partners and MB Venture Partners.

MAKO Surgical (Ft. Lauderdale, FL) developer of a guidance system that aids in surgery for early-stage osteoarthritis of the knee raised $30 million in Series C funding. Investors included Tudor Investment Corp., Ziegler Meditech Equity Partners, The Exxel Group, MDS Capital, Aperture Venture Partners, Ivy Healthcare Capital and Sycamore Ventures.

iBalance Medical (Boulder, CO) a developer of axial knee realignment systems, has expanded its Series A round to a total of $13.5M. Return backers include Sutter Hill Venture Partners and Skyline Ventures.