Otonomy (San Diego, CA) a clinical-stage biopharmaceutical company focused on, hearing and balance disorders such as Ménière’s disease, hearing loss, and tinnitus. closed a $38.5M Series B financing. Participants include Novo Ventures, RiverVest Venture Partners, Domain Associates and TPG Biotech.

Aptus Endosystems (Sunnyvale, CA) a clinical-stage medical device company focused on endovascular aneurysm repair, closed a $15M Series D financing. Participants include US Venture Partners and Longitude Capital.

Si-Bone (San Jose, CA) a commercial-stage medical device company focused on minimally-invasive approaches to sacroiliac joint disruptions and degenerative sacroiliitis, closed a $10.6M Series B. Participants include Skyline Ventures.

Complete Genomics (Mountain View, CA) a commercial-stage sequencing company building a human genome sequencing center to enable academic and biopharma researchers to conduct large-scale human genome studies, closed a $39M Series E financing. Participants include Sands Capital Management, Essex Woodlands, OVP Venture Partners, Prospect Venture Partners, OrbiMed Advisors, Highland Capital Management and Enterprise Partners.

Solazyme (San Francisco, CA) a development-stage synthetic biology company focused on algal biodiesel and industrial chemicals, closed a $52M Series D financing. Participants include Morgan Stanley Venture Partners, Braemar Energy Ventures, Lightspeed Venture Partners, Roda Group, Harris and Harris Group, VantagePoint Venture Partners, Zygote Ventures, Chevron Technology Venture Investments and San-Ei Gen.

BarRx Medical (Sunnyvale, CA) a clinical-stage medical device company focused on endoscopic treatment of precancerous lesions of the esophagus and other chronic gastrointestinal diseases, closed a $15M Series financing. Participants include Highland Capital Partners, Delphi Ventures, Alloy Ventures, Frazier Healthcare Ventures, Sutter Hill Ventures and Greenspring Associates.

TriVascular (Santa Rosa, CA) a commercial-stage medical device company focused on endovascular repair devices for the treatment of abdominal aortic aneurysms, closed a $60M Series C financing. Participants include Pinnacle Ventures, New Enterprise Associates, Delphi Ventures, MPM Capital and Kearny Venture Partners.

Ventus Medical (Belmont, CA) a commercial-stage medical device company focused on obstructive sleep apnea, closed a $40M Series D financing. Participants were not identified.

iPerian (San Francisco, CA) a development-stage induced pluripotent stem cell drug discovery company focused upon neurodegenerative disease including ALS and Parkinson’s, closed a $22M Series B financing. Participants include Google Ventures, Mitsubishi UFJ Capital, ATEL Ventures, MPM Capital, Highland Capital Partners and Kleiner Perkins Caufield & Byers.

ReVision Optics (Lake Forest, CA) a clinical-stage medical device company focused on a corneal inlay for presbyopia, closed a $35M Series D financing. Participants include ProQuest Investments, Domain Associates, Canaan Partners and InterWest Partners.