C8 MediSensors (San Jose, CA) a clinical-stage medical device company focused on non-invasive continuous glucose monitors, closed a $24M Series E financing. Participants have included GE Healthymagination Fund.

Aviir (Irvine, CA) a commercial-stage diagnostic company focused on pharmacogenomic and genetic tests for risk assessment and therapeutic monitoring of cardiovascular disease and related metabolic disorders, closed a $10M Series E financing. Participants include Merck Global Health Innovation, Bay City Capital, Aberdare Ventures and New Leaf Venture Partners.

Portola Pharmaceuticals (South San Francisco, CA) a clinical-stage small moelcule company focused on acute and chronic cardiovascular and autoimmune and inflammatory diseases, closed an $89M Series E financing. Participants included Temasek, Eastern Capital Limited, D.E. Shaw, Adage Capital Management, BBT Capital Management, Janus Capital Group and Pac-Link BioVentures.

Edison Pharmaceuticals (Mountain View, CA) a clinical-stage small molecule company focused on mitochondrial disease Friedreich’s ataxia, closed a $4.1M Series E financing. Participants were not identified.
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CardioKinetix (Redwood City, CA) a clinical-stage medical device company focused on transcatheter implants for congestive heart failure, closed a $44M Series E financing. Participants include SV Life Sciences, New Leaf Venture Partners, U.S. Venture Partners, J.P. Morgan Partners, H&Q Healthcare Investors and H&Q Life Sciences Investors.

Revance Therapeutics (Newark, CA) a clinical-stage biopharmaceutical company developing botulinum toxin type A products focused on topical indications such as lateral canthal lines and hyperhidrosis, closed a $45M Series E financing. Participants include Essex Woodlands Health Ventures, NovaQuest Capital, CNF Investments, Vivo Ventures, Technology Partners, Shepherd Ventures, Palo Alto Investors, Pac-Link Ventures and Essex Capital [...]

Neuronetics (Malvern, PA) a commercial-stage medical device company focused on pulsed magnetic field stimulation for non-invasive, non-systemic treatment of depression, closed a $30M Series E financing. Participants include Polaris Venture Partners, Pfizer Venture Investments, Investor Growth Capital, New Leaf Venture Partners, Interwest Partners, Three Arch Partners, Quaker BioVentures and Onset Ventures.

Cameron Health (San Clemente, CA) a commercial-stage medical device company focused on a subcutaneous implantable defibrillator platform, closed a $107M Series E financing. Participants include Alloy Ventures and Delphi Ventures.

Intrexon (Blacksburg, VA) a commercial-stage synthetic biology company focused on modular DNA control systems to enhance capabilities, improve safety and lower cost in human therapeutics, protein production, industrial products, agricultural biotechnology and animal science next generation synthetic biology company, closed a $100M Series E financing. Participants have included Third Security, New River Management, NewVa [...]

CardioDx (Palo Alto, CA) a commercial-stage cardiovascular molecular diagnostics company focused on coronary artery disease, cardiac arrhythmia and heart failure, closed a $60M Series E financing. Participants include Longitude Capital, J.P. Morgan, Acadia Woods Partners, Artian Ventures and Briht Capital.

Rib-X Pharmaceuticals (New Haven, CT) a clinical-stage small molecule drug discovery company developing antiinfectives against community acquired pneumonia, chronic bronchitis and complicated skin infections, closed a $20M Series E financing. Participants have included Warburg Pincus, ABS Ventures, Axiom Ventures, EuclidSR Partners, MedImmune Ventures, Oxford Bioscience Partners, SR One and Vox Equity Partners.

SymBio Pharmaceuticals (Japan) a commercial-stage pharmaceutical company focused on non-Hodgkin’s lymphoma, multiple myeloma and other hematological indications, closed a $24M Series E financing. Participants include Cephalon, Nippon Venture Capital, SMBC Venture Capital, MBL Venture Capital and JAFCO.

VertiFlex (San Clamente, CA) a clinical-stage medical device company focused on percutaneous and motion preserving spinal surgery technologies, closed a $14M Series E financing. Participants include New Enterprise Associates, Aberdare Ventures, Alta Partners and Thomas, McNerney & Partners.